Radionuclide imaging of breast cancer: experience of FSBI “N.N. Petrov National Medical Research Centre of Oncology” of the Ministry of Healthcare of Russian Federation

Abstract. Breast cancer is one of the most common malignant neoplasms among women nowadays. Timely diagnosis basis for effective and successful treatment this disease. The existing classical methods X-ray examination (MG, ultrasound, MRI) play a major role in detection breast cancer, but some cases, can be difficult. Therefore, diagnostic performance scintimammography with specialized gamma camera called molecular imaging (MBI) now particular clinical interest. Materials methods. 312 patients preliminary were examined department radionuclide diagnostics N.N. Petrov Research Center Oncology. They underwent manufactured by GE (Discovery 750b). Images both breasts obtained 15 min after intravenous injection 500 MBq activity 99mTc-MIBI. foci moderate intensive radiopharmaceutical accumulation considered as sign tumor. MBI sensitivity various biological subtypes calculated comparing results morphological immunohistochemically studies. Results. sensitivity, specificity accuracy 88, 75 87%, respectively. Sensitivity method different ranged from 89% to 95% lowest found luminal A subtype. Conclusion. Scintimammography an informative way diagnostics. revealed differences confirm need further study topic.